It has been recognized by forensic toxicology laboratories around the world that the abuse of prescription opioids for non-medical use has been on the rise over the past decade. The most commonly abused opioid is hydrocodone, a frequently prescribed pain medication. Laboratories have been requesting a sample prep column that would offer a rapid, efficient and reproducible methodology. UCT has responded with Xcel I and II SPE columns.
In a study recently published in Journal of Analytical Toxicology (September (2012;36:507–514)) Sandra Valtier and Vikhyat S. Bebarta of Lackland Air force Base, TX, demonstrated the use of the Xcel I column to determine the metabolites of hydrocodone i.e. hydromorphone, norhydrocodone in human urine. Their study describes the excretion profile of hydrocodone, hydromorphone and norhydrocodone in urine following a single dose (10 mg) administration of the drug to human subjects and presents a validated liquid chromatography– tandem mass spectrometry method for analysis of the drug and its metabolites. By showing that a LOQ was 5 ng/mL and LOD was 2.5 ng/mL for hydrocodone and norhydrocodone, and 5 ng/mL for hydromorphone were achievable through the use of Xcel I phase, it demonstrates how effective this SPE sorbent is in analyzing urine for these opiates.
UCT proudly stands behind its support of laboratories facing the increasing number of abused drugs by having a superior portfolio of SPE sorbents under the Clean Screen® banner. This line also includes the CSDAU and CSTHC range of sorbents, acknowledged around the world for their excellence in drug analysis.